APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| Assay dependent |
|
Note :
ELISA
For ELISA coating, recommend using BSA-free format (please contact us for PBS only format).
|
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
10mM PBS, 0.05% BSA
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant human Perforin-1 protein fragment (around aa 413-552) (exact sequence is proprietary)
Purification
Protein A/G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
FLH2 , HPLH2 , P1 , PFN1 , PFP , PRF1 , perforin 1 , Perforin
Cellular Localization
Cytoplasmic granule lumen,Secreted,Cell membrane,Endosome lumen
Background
This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
Database
Research Area
DATA IMAGES
![Anti-Perforin antibody [PRF1/2468] used in Protein Array (Protein Array). GTX17985](/templates/default/js/lightbox/images/loading.gif "Anti-Perforin antibody [PRF1/2468] used in Protein Array (Protein Array). GTX17985")
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GTX17985 Protein Array Image
Analysis of Protein Array containing more than 19,000 full-length human proteins using Perforin-1 Mouse Monoclonal Antibody (PRF1/2468). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.
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REFERENCE
There are currently no references for Perforin antibody [PRF1/2468] (GTX17985). Be the first to share your publications with this product.
REVIEW
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![Anti-Perforin antibody [PRF1/2468] used in Protein Array (Protein Array). GTX17985](/upload/website/prouct_img/small/GTX17985/GTX17985_20200115_Protein-Array_2075_w_23060620_642.webp "Anti-Perforin antibody [PRF1/2468] used in Protein Array (Protein Array). GTX17985")
![Anti-Perforin antibody [PRF1/2468] used in Protein Array (Protein Array). GTX17985](/upload/website/prouct_img/normal/GTX17985/GTX17985_20200115_Protein-Array_2075_w_23060620_642.webp "Anti-Perforin antibody [PRF1/2468] used in Protein Array (Protein Array). GTX17985")